Since the co-existence of both H4K16ac and H3K23ac was correlated with higher gene expression levels in a plant study, and lipopolysaccharide can trigger IL-6 production via enhancing recruitment of H3K23 acetylation to IL-6 promoter region, we speculated that the simultaneous hypoacetylation of H3K36 and H3K23 in OSA patients may lead to impaired DNA repair ability under chronic IHR circumstances, and affect specific adaptive gene responses through regulating HIF-1α22,23. The gene discussed is IL6; the disease is obstructive sleep apnea syndrome.