KDM6B and obstructive sleep apnea syndrome: Subgroup analysis showed that KDM6B protein expression was decreased in OSA patients with a high hypoxic load (n = 12, ODI > 70 events/hour; 0.2 ± 0.04 ng/μl; Fig. 2D) versus those without a high hypoxic load (n = 44; 0.25 ± 0.08 ng/μl, p = 0.017/adjusted p = 0.027) or PS subjects (0.26 ± 0.1 ng/μl, p = 0.036/adjusted p = 0.016).