In conclusions, H3K23/H3K36 hypoacetylation is associated with the development of prevalent hypertension or disease severity in patients with sleep-disordered breathing, probably through up-regulation of HDAC1, while H3K79 hypermethylation is associated with higher risk of incident cardiovascular diseases, probably through down-regulation of KDM6B. This evidence concerns the gene HDAC1 and cardiovascular disorder.