Furthermore, hypoxia inducible factor (HIF)-1α and HIF-2α promoter specific H3K36Ac and H3K23Ac enrichment was determined in another cohort of 8 PS subjects and 28 treatment-naïve OSA patients, and an in vitro IHR cell culture model was used to verify these molecular changes. Here, HIF1A is linked to obstructive sleep apnea syndrome.