HDAC3 protein expression was decreased in OSA patients with a high hypoxic load (1.5 ± 0.35 ng/μl; Fig. 2F) versus those without a high hypoxic load (1.8 ± 0.43 ng/μl, p = 0.024/adjusted p = 0.046) or PS subjects (1.83 ± 0.47 ng/μl, p = 0.031/adjusted p = 0.033). Here, HDAC3 is linked to obstructive sleep apnea syndrome.