Similarly, the adapter protein, AP2A2 was less represented, i.e., less O-GlcNAc-modified in the enriched placental lysates from mothers with T2D, and two of the predicted O-GlcNAc sites (S227 and S516) were identified as O-GlcNAc-modified by the current study (Table 2). The gene discussed is AP2A2; the disease is type 2 diabetes mellitus.