PIEZO1 and malignant colon neoplasm: MWS shares a musculoskeletal phenotype similar to DA5 and GS but is further characterized by hindbrain malformations and developmental delay.176 In addition to hereditary human diseases, PIEZO proteins are tightly associated with several cancers.177,178 Sun et al.179 reported that PIEZO1 was upregulated in colon cancer tissues, which was closely correlated with poor prognosis of colon cancer, and that PIEZO1 overexpression in vitro promoted the migration and metastasis of colon cancer cells.