Previously, Fam38A (also called KIAA0233 or Mib) was reported to be associated with astrocyte activation in senile plaque-associated Alzheimer’s disease progression31 and integrin activation in epithelial cells.32 For the first time, the Fam38A gene was reported to have an essential function in pressure-induced MA currents. Here, PIEZO1 is linked to early-onset autosomal dominant Alzheimer disease.