HEK cells stably expressing the aggregation competent Tau repeat-domain (amino acid residues 244–372) with mutations P301L/V337M fused to GFP (Tau-GFP) were exposed to homogenates extracted from affected brain regions from patients with AD, cortical basal degeneration (CBD), progressive supranuclear palsy (PSP) or frontotemporal lobar degeneration with Tau pathology (FTLD-Tau). The gene discussed is MAPT; the disease is Classical progressive supranuclear palsy.