Although Numb was strongly downregulated in iCCA, the iCCA patients were into the following two groups according to IHC staining: high Numb expression group (NumbHigh, score 4–9) and low Numb expression group (NumbLow, score 1–3) (Fig. S1B). The gene discussed is NUMB; the disease is infantile convulsions and choreoathetosis.