More importantly, we found ERp29 could elevate miR-135a-5p expression by decreasing IL-1β-induced methylation of miR-135a-5p promoter region, by which ERp29 forms a feedback regulation loop with miR-135a-5p, and maintains the expression balance between ERp29 and miR-135a-5p; the dysregulation of this loop may lead to CRC progression. Here, IL1B is linked to colorectal carcinoma.