Therefore, ERp29 increases miR-135a-5p expression via reducing IL-1β-induced methylation on the miR-135a-5p promoter region, and forms a regulation loop with miR-135a-5p, a mechanism by which normal cells maintain a balance between miR-135a-5p and ERp29 to prevent excessive growth, but maybe dysregulate in cancer cells owing to a robust increase in exogenous IL-1β produced by inflammatory cells in the microenvironment of CRC. The gene discussed is ERP29; the disease is cancer.