Furthermore, ERBB4 overexpression increased the expression of psoriasis-related genes and inflammatory genes, and the levels of phospho-STAT3 (Tyr705), phospho-STAT3 (Ser727), and phospho-NF-κB p65 (Ser311) in the presence or absence of M5 treatment (Fig. 7D, E). This evidence concerns the gene NFKB1 and psoriasis.