In addition, the critical cytokines IL-6 and IL-1 were found to be mainly produced by monocytes during CRS, while the concentration of IL-1β in the serum increased approximately 24 h earlier than that of IL-6, and the level of IL-1β in the serum was lower than that of IL-6 after CAR-T-cell infusion. The gene discussed is IL6; the disease is congenital rubella syndrome.