According to the important cytokines of CRS mentioned above, the present review illustrated the possible molecular and cellular mechanisms of CRS from several key cytokine-triggered signaling pathways, including TNF/NF-κB, IL-1/NF-κB, IL-6/JAK-STAT, and IFN-γ/JAK/STAT signaling pathways. The gene discussed is IL1B; the disease is congenital rubella syndrome.