In a mouse model of CRS, Mestermann et al. found that dasatinib halted cytokine production and proliferation of CAR-T cells and protected mice from otherwise fatal CRS, while the inhibitory effect was rapidly and completely reversed upon discontinuation of dasatinib.155 In addition, Sun et al. found that SHP1 recruitment induced by the transient administration of AP21967 significantly reduced the release of human IFN-γ, IL-6, GM-CSF, and TNF-α in the plasma of a humanized mouse model.157 At last, novel types of CAR are also a direction to fundamentally prevent CRS. This evidence concerns the gene TNF and congenital rubella syndrome.