IL1B and COVID-19: IL-1β may also contribute to CRS in coronavirus infections.142 In many autoinflammatory disorders, IL-1 is the critical player of the innate immune response and inflammation.143 Anti-IL1β antibody exerted separated and synergistic effects in preventing endothelial activation induced by tumor cells, CAR-T, and myeloid cells.138 In severe COVID-19, it was proposed that NLRP3 activation and IL-1β precursor cleavage potentially aggravate CRS.144