JAK1 and hemophagocytic syndrome: Glucocorticoids, cyclosporine, etoposide, anti-thymocyte globulin, and cytotoxic chemotherapies are effective in controlling both primary and secondary HLH by suppressing or eliminating T cells and other immune cells.101 In addition, anti-IL-1 antibodies, anti-IL-6 antibodies, JAK1 and JAK2 inhibitors, and anti-IFN-γ antibodies are also effective in blocking specific cytokines and controlling HLH.1