NF-κB/TNF disorders include haploinsufficiency of A20 (with TNFAIP3 gene disorder), OTULIN-related autoinflammatory syndrome (with OTULIN gene disorder), Blau syndrome (with NOD2 gene disorder), TNF receptor-associated periodic syndrome (with TNFRSF1A gene disorder), and deficiency of adenosine deaminase 2 (with ADA2 gene disorder). Here, OTULIN is linked to hyperinsulinemic hypoglycemia, familial, 4.