For example, studies on brain comparative transcriptomics indicated altered glial, endothelial and ATPase activity related to MDD [11]; Sha and Banihashemi detected a cerise of pathways including immune response and transmembrane transport, which were associated with regional grey matter volume change regional structural variations in MDD [13], A single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder found greatest dysregulation occurred in deep layer excitatory neurons and immature oligodendrocyte precursor cells [15]. The gene discussed is DNAH8; the disease is major depressive disorder.