Cancerous lesions had more infiltration of XBP1+CD68+ cells (white) compared to normal tissue (14.11 ± 1.10 vs. 3.40 ± 0.18; P < 0.0001), XBP1+CD206+ macrophages displayed the similar pattern (3.26 ± 0.37 vs. 1.07 ± 0.15; P < 0.0001) (Fig. 1j). The gene discussed is XBP1; the disease is cancer.