Furthermore, the infiltration of XBP1+ TAMs, especially XBP1+ CD206+ (representing the XBP1 activation in TAMs), in tumors was associated with shorter DFS in CRC patients, but not XBP1+EPCAM+ (representing the XBP1 activation in cancer cells) (Fig. 1k, l and Supplementary Fig. S2d, e). This evidence concerns the gene MRC1 and cancer.