Inhibiting IRE1 RNase activity in patient-derived xenograft models, using small molecule inhibitor 8866, restrained MYC-overexpressing tumor growth but did not reduce tumors expressing MYC.37 In APCmin/+ mouse model, epithelial-specific XBP1 deficiency was associated with a profound increase in tumorigenesis in CAC.38 The current study determined that XBP1 was present in both cancer cells and hTAMs sorted from CRC samples, whereas the amount of XBP1 present in TAMs was significantly higher than that present in cancer cells. Here, ERN1 is linked to cancer.