Intriguingly, frequent mutations of PROSER1 along with UTX, MLL3, and MLL4 have been described in esophageal squamous cell carcinoma (Gao et al, 2014), indicating that PROSER1/OGT/TET2 and the MLL3/4 complexes might converge in their tumor suppressive functions to protect certain CGIs and/or genomic elements such as enhancers from DNA methylation and thus silencing of associated genes. This evidence concerns the gene KMT2C and neoplasm.