NLRP3 and Cognitive impairment: We performed electrophysiological recordings of synaptic plasticity in PFC slices from mice 4 w after TBI and found that the LTP amplitude in NLRP3-KO mice was significantly higher than that in WT mice (Fig. 3A, B), which confirmed that timepoint cognitive impairment does exist and indicated that NLRP3 knockout has a protective effect on TBI-induced cognitive impairment of the hippocampus-PFC circuit.