Since cellular adhesion molecules such as ICAM-1 and VCAM-1 are involved in the adhesion of peripheral inflammatory cells such as lymphocytes and macrophages to endothelial cells in lesion area during MS and EAElow, we investigated the effect of Ki16425 treatment on their expression by real-time PCR analysis (Fig. 5J, K). Here, VCAM1 is linked to myeloid sarcoma.