Since cellular adhesion molecules such as ICAM-1 and VCAM-1 are involved in the adhesion of peripheral inflammatory cells such as lymphocytes and macrophages to endothelial cells in lesion area during MS and EAElow, we investigated the effect of Ki16425 treatment on their expression by real-time PCR analysis (Fig. 5J, K). The gene discussed is ICAM1; the disease is myeloid sarcoma.