6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 enzyme (PFKFB3) and FBP are two glycolysis regulators upregulated in chemoresistant cervical cancer cells, and they increase glycolytic levels (exhibiting high glucose uptake, high ATP levels and low oxygen consumption rates) in cervical cancer cells [72]. The gene discussed is PFKFB3; the disease is cervical cancer.