Dual αvβ6/αvβ1 inhibitor, PLN-74809, was tested alongside specific inhibitors of αvβ6 (3G9) and αvβ1 (Compound A) to confirm the respective role of these integrins in mediating primary human lung epithelial cell (n = 2 individual healthy donors) and primary human lung fibroblast (HLF; n = 3 individual healthy donors and n = 4 donors with IPF) adhesion to LAP. This evidence concerns the gene TGFB3 and idiopathic pulmonary fibrosis.