TGFBR1 and idiopathic pulmonary fibrosis: Approximately two-thirds of the TGF-β receptor I kinase-dependent (ALK5-dependent) collagen gene expression in lung explant cultures from patients with IPF could be suppressed by dual αvβ6/αvβ1 inhibition, demonstrating the significant role these two integrins play in driving collagen synthesis in the fibrotic human lung.