KRT78 and bacterial infectious disease: The top 5 of main regulators or hub genes of module 4 included genes involved in the keratinization process such as KRT78 (Keratin type II cytoskeletal 78), genes encoding calcium-binding proteins that play an antimicrobial function (S100A8, S100A9, S100A12) and TRIM29 (Tripartite Motif Containing 29) which is also involved in the response to viral and bacterial infections.