To assess the interaction of the HDL-C/apoA-I ratio and FT3 level with the risk of CAD, participants were divided into four groups (Group 1: FT3 > 4.5 pmol/L and HDL-C/apoA-I > 0.89 mmol/g; Group 2: FT3 > 4.5 pmol/L and HDL-C/apoA-I ≤ 0.89 mmol/g; Group 3: FT3 ≤ 4.5 pmol/L and HDL-C/apoA-I > 0.89 mmol/g; Group 4: FT3 ≤ 4.5 pmol/L and HDL-C/apoA-I ≤ 0.89 mmol/g). The gene discussed is APOA1; the disease is coronary artery disorder.