The main findings showed that patients in the lower median for the HDL-C/apoA-I ratio (≤ 0.89 mmol/g) and FT3 level (≤ 4.5 pmol/L) had the highest CAD risk (OR = 2.441, 95% CI = 1.717–3.470, P < 0. The gene discussed is APOA1; the disease is coronary artery disorder.