In HPV16+ cervical cancer line Caski and SiHa, the PD-L1 and HER2 transcript and protein expressions were significantly upregulated as compared to normal epithelial cells H8 (Fig. 3C, D), indicating PD-L1 and HER2 are closely associated with HPV16+ cervical cancer. This evidence concerns the gene ERBB2 and cervical carcinoma.