TP53 and clear cell renal carcinoma: For example, lncRNA DHRS4-AS1 functioned by preventing the proliferation and invasion, inhibiting the cell cycle progression and promoting the apoptosis of clear cell renal cell carcinoma [19]; lncRNA DHRS4-AS1 inhibited the stemness of non-small cell lung cancer Cells by Sponging miR-224-3p and Upregulating TP53 and TET1 [37]; and lncRNA DHRS4-AS1 was decreased in glioma and neuroblastoma [17,19], without further mechanism exploration.