Thereafter, the results of CCK-8, BrdU assay and colony-forming experiment exhibited that inhibition of miR-522-3p inhibitor would thereby restricted the proliferation of HCC cells; while knockdown of SOCS5 instead promoted cell growth of HCC, which suggested that down-regulation of SOCS5 was capable to reverse the HCC progress generated by miR-522-3p inhibitor (Figure 8(c–e)). The gene discussed is SOCS5; the disease is hepatocellular carcinoma.