HMOX1 and acute kidney injury: In our experiment, it was found that the expressions of Nrf2 and HO-1 in the nucleus were further inhibited after further administration of Fer-1, while the expressions of Nrf2 and HO-1 were reversed after administration of Fe, suggesting that rhADAMTS13 regulates the Nrf2 signaling pathway to inhibit ferroptosis, thereby improving acute kidney injury induced by CP.