To investigate the influence of CYP2J2 on Notch signaling in a hypoxia-induced ROP model, HRVECs were exposed to hypoxia for 24 h and transfected with pcDNA3.1(+)-GFP or pcDNA3.1(+)-CYP2J2. This evidence concerns the gene CYP2J2 and retinopathy of prematurity.