In the meantime, the dying tumour cells in the tumour microenvironment (due to the EDVs releasing cytotoxic drug intracellularly) release ‘find‐me’ signals such as low levels of nucleotides ATP and UTP, fractalkine, lysophosphatidyl choline, or sphingosine 1‐phosphate, which attract APCs to the sites of death within the tissue (Gregory, 2009). Here, CX3CL1 is linked to neoplasm.