The correlation between cytochrome c and COX-IV was attenuated in mice with B16-F10 tumors (correlation: r = 0.54, p = 0.0078; comparison between slopes vs tumor-free: p = 0.035; Table 4) and absent in mice with EO771 tumors (comparison between slopes vs tumor-free: p = 0.043). The gene discussed is COX4I1; the disease is neoplasm.