LPL and hypertriglyceridemia: Similarly, there is a familial hypertriglyceridaemia in humans, characterized by an increase in the production of VLDL [21,26] and apolipoprotein C-II (APOC2) deficiency, in humans is a very rare cause of hyperkylomycinemia, the most common cause is deficiency of lipoprotein lipase (LPL) [27].