GRN and hepatocellular carcinoma: Many CRISPR activators (CRISPRa) and CRISPR repressors (CRISPRi) have been reported for gene regulation applications (Figure 3D,E).[1c] For instance, Wang et al. synthesized dCas9 epi‐suppressors by fusing dCas9 to three epigenetic suppressor genes for HCC therapy.[43] They used this system to target the granulin (GRN), a promotive factor of pluripotent mitogen and growth in tumor progression.