For example, Xu et al. demonstrated that ctDNA methylation markers in the plasma were closely correlated to HCC DNA, providing a concept for a potential effective blood‐based diagnostic method.[73] Other markers, such as CTNNB1 and TP53, have been discovered and may be suitable for CRISPR‐mediated specific HCC detection.[74]. The gene discussed is CTNNB1; the disease is hepatocellular carcinoma.