SPP1 and hepatocellular carcinoma: Serum α‐fetoprotein (AFP) has been studied mainly as a reliable HCC marker in diagnostics and prognosis prediction.[71] Osteopontin (OPN) was identified as a matricellular protein in the bone matrix, relevant to HCC metastasis.[72] Recently, methylated DNA markers (MDMs) have been discovered as depicters for HCC‐specific genetic and epigenetic aberrations,[73] so they may be suitably applied for CRISPR/Cas‐based diagnosis, surveillance, and prognosis analysis.