Retroviruses and lentiviruses are also commonly used vectors.[92] These vectors have been widely used to transduce CRISPR/Cas9 elements to treat viral hepatitis and HCC.[24, 46, 93] Promisingly, to solve the problem of lentivirus‐mediated long‐lasting expression of CRISPR/Cas9 machinery, a report developed a lentivirus‐like bio‐nanoparticle (LVLP) delivery system for CRISPR mRNA in a “hit‐and‐run” manner for safe editing.[92] The SaCas9 mRNA was efficiently packaged in LVLP via specific interaction between MS2 (an RNA aptamer) and MS2‐binding protein termed MCP. The gene discussed is ADAM8; the disease is hepatocellular carcinoma.