BIRC5 and hepatocellular carcinoma: For example, Qi et al. developed a lactose‐derived branched cationic biopolymer (LBP) for HCC targeting via the binding of lactose and asialoglycoprotein receptor (ASGPR), which is highly expressed on the surface (Figure 11A).[104] With cationic polymers and reducible disulfide linkages, LBP was applied to deliver plasmid Cas9/sgRNA‐targeting survivin gene (Figure 11B) and showed excellent in vitro gene editing with 21.3% mutation (Figure 11C).