The representative example is a recent study of the HEK‐293T cell‐derived exosome decorated with aptamer‐conjugated tetrahedral DNA nanostructures (TDNs) to deliver CRISPR cargos (Figure 13A).[112] With the decoration of selected TDN1 (one TLS11a aptamer and three cholesterol anchors), the engineered exosome packaged the CRISPR RNP‐targeting WNT10B and enabled specific location in the tumor sites (Figure 13B). This evidence concerns the gene WNT10B and neoplasm.