NOS1 and hypertensive disorder: Moreover, SNPs in the human NOS1 gene correlate with hypertension (Iwai et al., 2004; Padmanabhan et al., 2010) and low urinary NO metabolites (NOx) excretion may be predictive of hypertension and/or kidney disease (Armas‐Padilla et al., 2007; Baumann et al., 2011; Hsu & Tain, 2019; Imanishi et al., 2013; Kemmner et al., 2017).