NFKB1 and inflammatory response: IL-17 is a newly discovered key pro-inflammatory factor, which will be imbalanced in the aged and increase the incidence of cardiovascular disease, CCD and AS (van Leeuwen et al. 2009), and it can accelerate the formation of AS by inhibiting autophagy function and promote the expression of other inflammatory factors, such as NF-κB, which pathway has been revealed as a key molecular system involved in pathological brain inflammation (Cai and Liu 2012; Tavridou et al. 2011).