FLT3 and acute myeloid leukemia: Internal tandem duplications in FLT3 (FLT3-ITD) occur in 20–35% of patients with de novo AML and tyrosine kinase domain (FLT3-TKD) mutations occur in 5–10% of patients with de novo AML (Heidel et al. 2006; Majothi et al. 2020; Marensi et al. 2021; Scholl et al. 2020).