Also coherent with previous reports (Dai et al. 2013; Li et al. 2019a; Qi et al. 2015; Xie et al. 2013; Zhao et al. 2017; Zhou et al. 2015), we found that the HDACi-induced loss of CHK1, WEE1, p21, and RAD51 was associated with cell cycle dysregulation and an accumulation of DNA strand breaks in AML cells with FLT3-ITD. This evidence concerns the gene CHEK1 and acute myeloid leukemia.