CGAS and Insulin resistance: The cGAS‒STING pathway is highly enriched in immune cells in metabolic tissues including the liver and adipose tissue, and activation of this pathway may promote inflammation, leading to a detrimental microenvironment in the tissues that causes insulin resistance or hepatosteatosis (Bai et al., 2017; Luo et al., 2018; Bai and Liu, 2019; Wang et al., 2020b).