Consistent with a negative role of adipose cGAS‒STING signaling in regulating thermogenesis, adipose-specific knockout of TBK1 attenuates HFD-induced obesity by increasing energy expenditure, which has been attributed to increased AMPK activity that enhances catabolism (Zhao et al., 2018). The gene discussed is TBK1; the disease is obesity due to melanocortin 4 receptor deficiency.