The cGAS‒STING signaling pathway has received considerable attention over the past years due to its pivotal roles not only in innate immune surveillance but also in many other previously unrecognized biological functions, e.g. regulating nonalcoholic or alcoholic liver disease (Bai et al., 2017; Luo et al., 2018; Yu et al., 2019), fat tissue thermogenesis (Bai et al., 2020), kidney diseases (Allison, 2019; Chung et al., 2019; Maekawa et al., 2019), and neurodegeneration (Gamdzyk et al., 2020; Jauhari et al., 2020; Paul et al., 2021). Here, STING1 is linked to kidney disorder.