Expression of foetal organoid enriched genes such as Anxa1 and Tacstd2/Trop are up-regulated within the regenerating intestinal epithelium [35] and differences in disease characteristics between right versus left sided colon cancer pathogenesis may be attributed to Lgr5+ versus Lgr5− Sca-1+ ISC populations [36]. Here, LGR5 is linked to malignant colon neoplasm.