AKT1 and Huntington disease: Neurodegenerative diseases such as Alzheimer, Parkinson, and Huntington disease are associated with the Akt signal defect.[16,32–34] Hence, PI3K/Akt activation by adropin may have therapeutic potential in neurodegenerative disorders.[33,35] Adropin activates Akt by phosphorylation induction.[10] Phosphorylated-Akt ensures cell cycle, proliferation, differentiation, and survival.[36,37] This path also triggers the mTOR pathway.