LEP and myeloid sarcoma: Adipokines are among the hormones whose effects have been investigated in MS for several years.[5–8] Leptin is an adipokine secreted from white adipose tissue and virtually affects the neuroendocrine system and immunomodulation.[5] Some previous studies focused on the relationship between leptin levels and MS, yet those earlier studies are still inconsistent.[6–8] Xie et al[7] found that higher serum leptin levels were found in MS patients compared with the control group.