BRAF and thyroid nodule: The sensitivity (89.57%) for the detection of malignant thyroid nodules, negative predictive value (NPV; 45.45%) for the detection of benign nodules, and accuracy (86.26%) for distinguishing between benign and malignant thyroid nodules increased in the combination of the BRAF V600E mutation test and TBSRTC system when compared to the BRAF V600E mutation test and TBSRTC system, respectively.