Among the patients receiving radical TRT, some local advanced patients with large tumor burden first, administered PD‐(L)1 inhibitor combined with chemotherapy to reduce the tumor burden as much as possible and then received radical TRT to control the lesions, while other advanced oligometastatic patients mainly with single distant metastasis received radical TRT when the distant metastasis was well controlled almost to complete response. This evidence concerns the gene CD274 and neoplasm.