The utility of PopHumanVar has been tested on frequently reported candidate genomic regions in genome-wide scans for positive selection in humans, including a region close to the gene EDAR, which is associated with hair follicle thickness and straightness and shovel-shaped incisors in East-Asians (31–34), a region in the gene ACKR1 (DARC), which is associated with resistance to malaria in Africans (35–37), as well as a region close to the genes LCT and MCM6, which is associated with lactase persistence in Europeans (38,39). This evidence concerns the gene LCT and malaria.