We previously showed by RT-qPCR analysis that the expression of both Rdh12 and Abca4, two genes that contribute to the visual cycle, was reduced in the retina of Prom1-KO mice compared with that of WT mice at P14 (Dellett et al., 2015), and we suggested that impairment of the visual cycle might lead to retinal degeneration. Here, ABCA4 is linked to retinal degeneration.