There are multiple reported common variants in SEZ6 which have been linked to diseases such as febrile seizure, epilepsy, Alzheimer’s disease and schizophrenia (Yu et al. 2007; Jiang et al. 2012; Ambalavanan et al. 2016; Paracchini et al. 2018). Here, SEZ6 is linked to early-onset autosomal dominant Alzheimer disease.