CASP3 and cancer: Among general candidates of anti‐cancer pathway, the PTX/CBP treatment on the BRCA‐wt group (Patient # 1–4 and 7) predominantly affected apoptosis signaling,[20] as evidenced by a significantly enhanced expression of PARP and cleaved caspase 3 and lower expression of Cyclin D1 and PCNA, compared to the no‐treatment group (PBS vehicle control) (Figure 1g).