HES1 and cancer: With respect to insight into anti‐cancer signaling of CaNV+MB‐Drug (Figure 2j), the expression of Notch‐1 downstream factors (cleaved Noth‐1 and HES‐1) significantly increased, while Notch‐1 expression remained unchanged, indicating Notch‐1 pathway as a major mechanism to drive the CaNV+MB‐Drug effect.