Furthermore, the mRNA expression levels of several genes coding for cortisol synthesis enzymes (CYP11A1, CYP17A1, CYP21A2) and steroid metabolism transcription factors (PDX1, NR5A1) were upregulated in CS‐ACC and associated with decreased CD8+ T‐cell infiltration. Here, CYP11A1 is linked to adrenal cortex carcinoma.