Furthermore, the mRNA expression levels of several genes coding for cortisol synthesis enzymes (CYP11A1, CYP17A1, CYP21A2) and steroid metabolism transcription factors (PDX1, NR5A1) were upregulated in CS‐ACC and associated with decreased CD8+ T‐cell infiltration. The gene discussed is CYP17A1; the disease is adrenal cortex carcinoma.