CFL1 and amyotrophic lateral sclerosis: Furthermore, cultured A. kurodai sensory-motor neuron co-cultures were used to investigate the formation and deleterious effects of cofilin-actin rods, hypothesized to be the precursors to the protein aggregates that typify AD and ADRDs like Parkinson’s disease and amyotrophic lateral sclerosis, via overexpression of the native cofilin gene (Jang et al. 2005).