Disruption of CREB signaling in cognitive centers has been observed in AD brains as well as rodent and neuronal models of AD and is suggested to be a major component of AD-associated cognitive impairment (Puzzo et al. 2005; Snyder et al. 2005; Tong et al. 2001; Vitolo et al. 2002; Yamamoto-Sasaki et al. 1999). This evidence concerns the gene CREB1 and Cognitive impairment.