Increased proteostatic stress in AD due to Aβ plaques and tau neurofibrillary tangles has been demonstrated to increase eIF2 phosphorylation, suggesting increased ISR activity in AD (Chang et al. 2002; Ferrer 2002; Hernandez-Ortega et al. 2016; Hoozemans et al. 2005, 2009). The gene discussed is MAPT; the disease is Alzheimer disease.