GC can be molecularly divided into four subtypes: the chromosomal instability (CIN) subtype with frequent TP53 mutations and RTK-RAS pathway amplifications; the genomically stable (GS) subtype displaying diffuse tumor morphology and CDH1 as well as RHOA alterations; the microsatellite instability (MSI) subtype with a hypermutation phenotype; and the Epstein-Barr virus-positive (EBV) subtype showing frequent PIK3CA mutations and silencing of CDKN2A51. The gene discussed is TP53; the disease is neoplasm.