KMT2A and leukemia: In the KMT2Ar leukemia samples, the correlation between the KMT2A N-terminal and C-terminal profiles was significantly lower than in the control samples (r = 0.53 ± 0.21; Extended Data Fig. 1a,c), and many of the wide KMT2A-bound regions showed an enriched KMT2A N-terminal signal relative to the KMT2A C terminus (Fig. 1b,c).