Grouping H3K4me3-marked promoter regions by t-SNE also partitioned 64 AML- and 508 ALL-specific elements to opposite sides of the t-SNE graph and identified 1,918 elements that were shared with the MPAL samples and CD34+ HSPCs (Fig. 2h and Extended Data Fig. 6g,h); however, as compared to H3K4me1, where we identified 23,828 lineage-specific peaks among the 56,267 total peaks (~40%), a smaller proportion of H3K4me3-marked features showed any lineage specificity (2,490/13,998 peaks, or ~18%). This evidence concerns the gene CD34 and acute lymphoblastic leukemia.