Replicate profiles for each mark in control CD34+ samples and KMT2Ar leukemia samples were very similar and were merged for further analysis (H3K27me3, r = 0.93 ± 0.051; H3K4me3, r = 0.96 ± 0.015; H3K4me1, r = 0.90 ± 0.037; H3K9me3, r = 0.83 ± 0.060; H3K27ac, r = 0.80 ± 0.077; H3K36me3, r = 0.95 ± 0.021; H4K16ac, r = 0.97 ± 0.012; RNAP2S5p, r = 0.77 ± 0.107) (Extended Data Fig. 4d). The gene discussed is CD34; the disease is leukemia.