This analysis revealed that H3K4me1-marked regions were highly variable between lineage subtypes, with a substantial fraction of elements marked specifically in AML samples falling to one side of the t-SNE plot (8,221/56,267), ALL-specific elements partitioned to the other side of the plot (8,466/56,267) and CD34+ HSPC elements grouped in the middle (7,141/56,267) (Fig. 2g and Extended Data Fig. 6e,f). Here, CD34 is linked to acute lymphoblastic leukemia.