Consistent with the activation of RIPK1 by SARS-CoV-2 infection in the lungs of COVID-19 patients, activated RIPK1 was also found in the lungs of SARS-CoV-2-infected AC70 transgenic mice and was reduced in the lungs of the mice treated with Nec-1s (Fig. 5f). This evidence concerns the gene RIPK1 and COVID-19.