However, we demonstrated increased collagen deposition, gene overexpression of Col1a1, and mild centrilobular/pericellular fibrosis in some animals, indicating that maternal diet-induced obesity leads to increased risk of liver fibrosis in the older offspring at 12 months of age, which could progress if the animals were aged further. This evidence concerns the gene COL1A1 and obesity due to melanocortin 4 receptor deficiency.