Focusing on the most relevant oncogenic pathways (Supplementary Table 6), we found that tumor cells in the CP2E environment receive potential paracrine signals from cancer-associated myofibroblast cluster 2 activating Ephrin, FGF, WNT, TGFβ, and BMP signaling, and from proinflammatory monocyte-derived macrophages cluster 2 potentially activating JAK/STAT signaling (Fig. 5D, Supplementary Fig. 10). The gene discussed is TGFB1; the disease is cancer.