TGFB1 and neoplasm: We identified cancer-associated myofibroblasts as potential sources of TGFβ ligands in the CP2E pattern, while EGFR interactions were equally present in both patterns, underlining that signaling pathways in tumor cells can be activated extrinsically via paracrine signals from the microenvironment but also via other mechanisms, e.g., intrinsically via oncogenic mutations.