Tumor endothelial cells were mainly represented by clusters 2 and 4 (Fig. 3A), and showed high expression of angiogenesis markers such as VWA1 and HSPG2, as well as INSR, encoding an endothelial marker protein and possible therapeutic target [9] (Supplementary Fig. 6B, arrowheads). The gene discussed is INSR; the disease is neoplasm.