NOS3 and hepatocellular carcinoma: As seen in Supplemental Fig. 1, the Ti/Te ratio rose equally in male and female WT and eNOS-/- mice (due to a relatively greater shortening of Te than Ti) during the HCC, whereas Ti/Te fell below baseline in both the male and female WT and eNOS-/- mice upon return to room-air (due to the more rapid return of Te toward baseline).