Moreover, the total responses during the HCC (Panel E, column HC) of the PIF/PEF ratio fell slightly in the eNOS-/- females, but not WT females, however this drop in PIF/PEF ratio did not reach statistical significance.  Upon return to room-air, the PIF/PEF ratio rose to similar levels in both groups at the 5 and 15 min time points,  (Panels A–E) due to a greater relative fall in PIF than PEF (Figs. 8 and 9, respectively). The gene discussed is NOS3; the disease is hepatocellular carcinoma.