Our data shows that (1) the ventilatory responses during and after HCC were similar in male and female C57BL6 WT mice; (2) the responses during and after HCC in male eNOS-/- mice were substantially smaller than in male WT mice; and (3) the responses in female eNOS-/- mice during and after HCC were similar to those in female WT mice. This evidence concerns the gene NOS3 and hepatocellular carcinoma.