NOS3 and type 2 diabetes mellitus: To establish validity of mouse model susceptibility to VT/VF in the context of DKD, we selected genetic (Leprdb/db eNOS−/−, hereafter referred to as 2KO) and inducible (six months HFD + low dose STZ at three months, hereafter referred to as HFD + STZ) models of type 2 diabetes and DKD for further study.