CD34 and acute myeloid leukemia: Since chromatin states in monocytes are likely not a good proxy for AML blasts, we also calculated the proportion of hypermethylated sites in AML that were located in enhancers from the Roadmap Epigenomics ChromHMM annotation of CD34+ hematopoietic stem cells (HSCs), and found a higher degree of enrichment for enhancer regions (15% in HSCs vs 8% in monocytes, P < 1 × 10−16, χ2 test).