Using TCGA data we show that TET2 mutations in AML are associated with hypermethylation at many of the same sites as in CHIP and CCUS, but also at a large number of AML-specific sites, which are unaffected in CHIP and CCUS, especially in regions that are enhancers in HSCs but not in monocytes. The gene discussed is TET2; the disease is acute myeloid leukemia.