TET2 and myeloid neoplasm: Two recurrently mutated genes with opposing effects on DNA methylation are ten-eleven translocation methylcytosine dioxygenase 2 (TET2) and DNA methyltransferase 3A (DNMT3A), both of which are especially frequently mutated in myeloid neoplasms and in the related conditions clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined significance (CCUS).