In our scRNA-seq cohort, Case 10 represented a typical example of BRAF-like-B subtype who demonstrated an advanced primary tumor with prominent immune infiltration, positive expression of BRAFV600E-mutant protein and programmed death-ligand 1 (PD-L1) protein (Fig. 5e), and further studies with more BRAF-like-B samples are required for further verification. The gene discussed is BRAF; the disease is neoplasm.