As these genes purely represented the profiling of thyroid epithelial lineages rather than miscellaneous tumor components, we thus aimed to refine the conventional BRAF-/RAS-like molecular subtyping algorithm4 based on PAGs using a cohort integrating two bulk RNA-seq profiles (TCGA and PRJEB11591, Supplementary Data 5; “Methods”). This evidence concerns the gene BRAF and neoplasm.