Among the five sorafenib-sensitive HCC cell lines — i.e., Huh7, HepG2, MHCC-LM3, MHCC-97H, and Hep3B — the expression of RCN1 was the lowest in Huh7 cells and the highest in Hep3B cells (Fig. S2A). This evidence concerns the gene RCN1 and hepatocellular carcinoma.