Previous studies have identified GADD34- and CReP-containing PP1c complex as phosphatases of eIF2α; [20, 33, 34]; however, the effects of these PP1 complexes on eIF2α phosphorylation have only been examined in non-cancer cells and neither of the complexes has been implicated in regulating chemosensitivity. The gene discussed is EIF2A; the disease is cancer.